P01.13.A The effect of musicality on language recovery after awake glioma surgery

Abstract Background Awake craniotomy is used to resect tumor while preserving language. However, differences between patients in post-operative speech/language outcome are observed despite careful intra-operative monitoring. Literature describes improved performance language tasks during cognitive tests musicians. Moreover increased white matter connectivity properties the corpus callosum described musicians compared non-musicians. We hypothesize better recovery of musical after awake glioma surgery, caused by higher from callosum. Material and Methods Adult undergoing resection for with an procedure at two neurosurgical centers were prospectively included. Patients without standardized pre- level, a glioblastoma multiforme (WHO grade 4) or re-resection excluded. Language was assessed Diagnostic Instrument Mild Aphasia (DIMA) corrected age education years healthy population. The patients’ skill through questionnaires, divided groups based on Musical Expertise Criterion (MEC) which defines musicality duration intensity training. Volumetric measures callosum, total brain volumes, calculated each included patient pre-operative structural MRI. Results Forty-six patients, enrolled June 2015 September 2019, followed-up (mean/SD; 240/174 days craniotomy) in: non-musician (41.3%, n = 19), amateur-musician (34.8%, n=16) trained-musician (23.9%, 11). Overall decrease (mean/SD) -0.361/0.771. abilities correlated less when comparing non-musicians (-0.543/0.683) amateur (-0.272/0.910) trained (-0.176/0.693) An but non-significant trend (p=0.28) / ratio (0.763, 0.718;0.808), (0.792, 0.745;0.838) (0.835, 0.778;0.891). Conclusion Musicality seemed improve possibly attributed due Future studies larger sample sizes needed confirm our findings.